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Etizolam (trade names Etilaam and Etizest) is a short-acting drug that is psychoactive of thienodiazepine course which has been demonstrated to create depressant, anxiolytic, sedative, hypnotic, muscle tissue relaxant, anticonvulsant, and amnestic effects. Etizolam, like benzodiazepines, binds to modulatory sites in the GABA acid that is gamma-aminobutyric. Etizolam just isn’t commonly recommended and it is perhaps not recognised as a controlled substance in many elements of the planet, leading to its increase in popularity as a product of many research chemical vendors.

Etizolam has a somewhat fast onset of action and symptomatic relief. 1mg of etizolam is about equal to 10mg diazepam. For anxiety disorders linked with despair, 1 mg is administered times that are several the length of a day. Smaller doses may alleviate symptoms of panic and will be utilized before bed for relief of insomnia.

Comparable to benzodiazepines, sudden withdrawal from extensive thienodiazepine usage can lead to high blood pressure, seizures, and death.[2] When suspending long-term usage, it’s extremely suggested to taper a person’s dose by slowly lowering the quantity taken each day for a prolonged time frame rather than stopping suddenly.[3]


Etizolam is a structural relative of benzodiazepines, whereby the benzene band has been changed by a ring that is thiophene classifying it as a thienodiazepine. Thiophene is a five member ring that is aromatic one sulfur atom. Etizolam contains a thiophene ring fused to a diazepine ring, that is a seven member band utilizing the two nitrogen constituents found at R1 and R4. This types the thienodiazepine core of etizolam. An ethyl string is bound to this bicyclic structure at R7. Furthermore, a fluorine that is r2 phenyl ring is likely to this structure at R5. Etizolam also contains a methylated triazole ring fused to and incorporating R1 and R2 of its diazepine ring. Etizolam shares this fused triazole ring substitution with certain drugs that are benzodiazepine called triazolobenzodiazepines, distinguished by the suffix “-zolam”.


Thienodiazepines produce a number of effects by binding towards the benzodiazepine receptor site and magnifying the effectiveness and ramifications of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors.[4] As this site is the absolute most respected inhibitory receptor inside the mind, its modulation results in the sedating (or soothing impacts) of etizolam in the nervous system.

Subjective effects

The effects down the page are based upon the effects that are subjective and personal experiences of PsychonautWiki contributors. The detailed results will rarely (if ever) occur all at as soon as, but weightier dosages will raise the chances and are more likely to induce a full array of effects.
Physical results

The physical effects of etizolam can be broken down into several components which progressively intensify proportional to dosage.
These are described below and generally include:

  • Sedation – In regards to energy level alterations, this drug has got the prospective to be incredibly sedating and often leads to an overwhelmingly lethargic state. At greater levels, this causes users to suddenly feel as though these are typically acutely sleep deprived while having not slept for several days, forcing them to stay down and generally feel as if they’re constantly on the verge of fainting alternatively of doing physical activities. This sense of sleep starvation increases proportional to dosage and finally becomes powerful enough to force someone into complete unconsciousness.
  • engine control loss
  • Respiratory depression
  • Muscle leisure
  • Dizziness
  • Temporary erection dysfunction

Cognitive effects

The cognitive results of etizolam can be broken on to several components which intensify proportional to progressively dosage. The basic head space of etizolam is described by many as you of recreationally intense sedation and reduced inhibition. It has a number that is large of depressant cognitive impacts.
Probably the most prominent of these effects that are cognitive include:

  • Anxiety suppression
  • believe deceleration
  • Disinhibition
  • Information processing suppression
  • Compulsive redosing
  • Amnesia
  • Delusions of sobriety – this is certainly the false belief that one is completely sober despite obvious proof towards the contrary such as serious cognitive disability and a failure to totally keep in touch with others.

Paradoxical effects

Paradoxical reactions to benzodiazepines such as increased seizures (in epileptics), aggression, increased anxiety, violent behavior, lack of impulse control, irritability and suicidal behavior sometimes happen (although they have been rare into the basic population, with an incidence price below 1%).[5][6]
These effects that are paradoxical with greater regularity in recreational abusers, individuals with psychological problems, kids, and patients on high-dosage regimes.[7][8]

Poisoning and damage potential


Blepharospasms (twitching eyelid) can occur with long-lasting use. Hardly ever, erythema annulare centrifugum skin lesions have been reported.
Deadly dosage

The lethal dose of etizolam have not been founded; however, like numerous benzodiazepines, it offers a large index that is therapeutic margin of safety. Problems may arise whenever administered in excess. Intentional overdoses are reported.

As with every GABAergic drugs, overdose is life-threatening whenever mixed with other depressants including liquor or opioids.
It is strongly suggested any particular one usage harm reduction methods whenever using this drug.
Addiction and tolerance potential

Tolerance will develop to your effects that are sedative-hypnotic a couple of times of duplicated management. Abrupt discontinuation of etizolam following dosing that is regular several times can lead to a withdrawal period which includes rebound signs such as increased anxiety and sleeplessness. It will be possible to slowly reduce the dosage during the period of several times, that may lengthen the timeframe regarding the withdrawal period, but reduce the identified intensity.
Thienodiazepine discontinuation is notoriously difficult; it really is potentially deadly for people making use of frequently to discontinue use without tapering their dose over a period of days. There is certainly an increased risk of seizure following discontinuation of Etizolam. Medications which lower the seizure limit such as tramadol should really be avoided during withdrawal.

Etizolam may not be cross-tolerant with a few other thienodiazepines or benzodiazapienes such as for instance diazepam, meaning the tolerances to these substances develop independently. This also means that the usage of diazepam or comparable substances may well not fully relieve the withdrawal signs and symptoms of etizolam or offer relief from the possibly lethal withdrawal signs whatsoever.
Dangerous interactions

Although a lot of medications are safe on the own, they can be dangerous and even deadly whenever combined with other substances. Record below contains some common combinations that are potentially dangerous but might not consist of all of those. Certain combinations could be safe in low doses of each but nevertheless raise the risk that is potential of. Separate research should be done to always ensure that a combination of two or even more substances is safe before usage.

  • Depressants (1,4-Butanediol, 2-methyl-2-butanol, liquor, barbiturates, GHB/GBL, methaqualone, opioids) – This combination might result in dangerous or also fatal levels of respiratory despair. These substances additionally potentiate the muscle leisure, sedation and amnesia caused by one another and may lead to loss that is unexpected of at high doses. There is additionally an elevated risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should asleep attempt to fall within the recovery position or have a friend move them into it.
  • Dissociatives – This combination can lead to an increased risk of vomiting during unconsciousness and death through the suffocation that is resulting. If this does occur, users should try to fall asleep in the data recovery place or have a pal move them involved with it.
  • Stimulants – It is dangerous to mix benzodiazepines with stimulants because of the danger of exorbitant intoxication. Stimulants reduce steadily the sedative aftereffect of benzodiazepines, which could be the factor that is main people give consideration to when determining their degree of intoxication. When the stimulant wears down, the ramifications of benzodiazepines will be significantly increased, leading to disinhibition that is intensified well as other results. If combined, you need to strictly limit by themselves to just dosing a certain number of benzodiazepines each hour. This combination can additionally possibly lead to serious dehydration if hydration isn’t supervised.